VELOX
Latin for "rapid" - VELOX is a ready-to-use, biocompatible and osteoconductive calcium phosphate bone cement, supplied pre-filled in a syringe for immediate use with no preparation and no time pressure during application.
What VELOX is made of
| Calcium carbonate | ✓ |
|---|---|
| Calcium hydrogenphosphate | ✓ |
| α-Tricalcium phosphate | ✓ |
| Precipitated hydroxyapatite | ✓ |
| Non-hydrous carrier liquid | ✓ |
Supplied as a 3cc prefilled syringe. Manufactured by INNOTERE GmbH, Radebeul, Germany.
Time matters
VELOX only begins to set on contact with a humid environment - not inside the syringe - so there is no time restriction during application. It is applied directly from the syringe into the bone defect.
10 minutes
Dimensional stability is achieved
24 hours
Becomes as hard as cancellous bone
7 days
Becomes similar to natural bone structure
Compressive strength rises steadily after setting begins, reaching roughly 45 MPa - about 3-4 times the strength of healthy cancellous bone - after around 4 days, depending on volume applied and vascular supply. After setting, VELOX forms a calcium-deficient hydroxyapatite, the major mineral constituent of natural bone.
Filling and reconstructing bone defects
VELOX is intended for filling or reconstruction of non-load-bearing bone defects, or defects stabilized by other appropriate means, and to augment temporary osteosynthesis fixation. Bone voids commonly need treatment after:
Trauma
Accidents and falls, e.g. metaphyseal defect fractures, or filling defects after fixation, removal or revision of osteosynthetic implants.
Reconstruction
Restoring bone function and form, for example after removal of cancerous tissue.
Correction
Addressing congenital bone defects.
Designed for the operating room
- No preparation necessary - ready to apply directly from the syringe.
- No time constraint during application, since setting only starts in a humid environment.
- Reduced risk of migration from the application site, and can be applied arthroscopically.
- Supports osteosynthesis and is progressively remodeled into the patient's own bone.
Long-term remodeling evidence
A histological evaluation of a novel ready-to-use, self-setting calcium phosphate bone substitute cement in a sheep implantation model (drill-hole defects, distal femur and proximal tibia) showed active resorption and remodeling from 4 weeks, near-complete osseointegration at 3 months, and complete integration into lamellar bone by 6-18 months, with no decline in osseointegration observed over the study period.
Source: Nies, B. A histological evaluation of a novel ready-to-use, self setting Calcium phosphate bone substitute cement in a sheep implantation model, in collaboration with the Laboratory for Experimental Traumasurgery of the University Hospital of Giessen and Marburg. INNOTERE GmbH, 2013.