hyaDENT BG
The world's first injectable hyaluronic acid dental treatment - a prefilled, ready-to-use cross-linked HA gel that works at a cellular level to promote healing and regeneration of gum, bone and periodontal tissue.
What's in each 1.2 ml cartridge
| Hyaluronic acid, cross-linked | 16 mg/ml |
|---|---|
| Hyaluronic acid | 2 mg/ml |
| Sodium chloride | 6.9 mg |
| Water for injection | ad 1.2 ml |
Non-animal source, chemically modified for dental use. Manufactured by BioScience GmbH, Dümmer, Germany. hyaDENT BG is not a dermal filler - its effect works at the cellular level to facilitate tissue healing and regeneration, not simply hydration or volumizing.
Cross-linking that protects and prolongs
Cross-linking transforms hyaluronic acid's straight-chain molecule into a 3D mesh, protecting it from rapid breakdown by hyaluronidase. Combined with non-modified HA, this gives hyaDENT BG both immediate and long-lasting effects.
8× longer stimulatory effect than PRF
A comparative study (Peck et al.) found the stimulatory effect of hyaDENT BG on wound healing is prolonged over 8 days, versus 1 day for platelet-rich fibrin (PRF).
Reduces swelling, pain & trismus
A randomized, double-blind study at King Abdul Aziz University Dental Hospital found statistically significant reductions in facial swelling, pain and trismus after third molar extraction (Nadershah et al.).
Bacteriostatic effect
Medium and lower molecular weight HA shows a bacteriostatic effect against common periodontal pathogens, including A. actinomycetemcomitans, P. oris and S. aureus.
A versatile addition to the dental practice
Interdental papilla loss
Injected in 3-4 droplets 3-4mm below the papilla using the Three-Step Technique (developed by Dr. Gottfert), then massaged for one minute. In supporting studies, 67% of patients reported being very satisfied with their smile post-treatment, compared with 22% pre-treatment.
Gingivitis & periodontitis
Non-surgically, hyaDENT BG is injected along the mucogingival junction after scaling/root planing and spread topically over the gingiva. Surgically, it is mixed 1:1 with bone graft to support tissue regeneration during flap procedures.
Gingival recession
In an 18-month controlled trial (Pilloni et al.), adjunctive use of cross-linked HA in coronally advanced flap surgery achieved 80% complete root coverage versus 33.3% for surgery alone, with lower postoperative swelling and discomfort.
Dental implant osseointegration
Applied as a coating on implants before placement into bone, and combined with biphasic calcium phosphate to accelerate new bone formation around osseous defects.
Socket preservation
Mixed 1:1 with bone graft to promote blood clot stabilization, support osseointegration of the graft material, and preserve adjacent soft tissue after extraction.
Sinus lift (sinus augmentation)
Improves handling of bone graft material during sinus augmentation and helps prevent graft migration in the atrophic posterior maxilla.
View cited references
- Ghazi, K. et al. Hyaluronan Fragments Improve Wound Healing on In Vitro Cutaneous Model through P2X7 Purinoreceptor Basal Activation. PLOS ONE, Nov 2012.
- Lorenz, H.P. and Adzick, N.S. Scarless skin wound repair in the fetus. The Western Journal of Medicine, Sep 1993.
- Peck, M., Hiss, D., Stephen, L. and Olivier, A. (2018). The in vitro effect of leukocyte- and platelet-rich fibrin (L-PRF) and cross-linked hyaluronic acid on fibroblast viability and proliferation. SADJ, 73(6), pp.395-399.
- Singh, V.P., Uppoor, A.S., Nayak, D.G. and Shah, D. (2013). Black triangle dilemma and its management in esthetic dentistry. Dental Research Journal, 10(3), 296-301.
- Shamma, M., Ayad, S., El-dibany, R. and Nagui, D. (2017). Evaluation of the effect of hyaluronic acid mixed with biphasic calcium phosphate on bone healing around dental implants. Alexandria Dental Journal.
- Dahiya, P. and Kamal, R. (2013). Hyaluronic acid: A boon in periodontal therapy. North American Journal of Medical Sciences, 5(5), p.309.
- Awartani, F.A. and Tatakis, D.N. Interdental papilla loss: treatment by hyaluronic acid gel injection: a case series. Springer-Verlag Berlin Heidelberg, 2015.
- Wang, F., Garza, L.A., Kang, S. et al. In Vivo Stimulation of De Novo Collagen Production Caused by Cross-linked Hyaluronic Acid Dermal Filler Injections in Photodamaged Human Skin. Arch Dermatol., 2007.
- Mueller, A., Fujioka-Kobayashi, M., Mueller, H., Lussi, A., Sculean, A., Schmidlin, P. and Miron, R. (2016). Effect of hyaluronic acid on morphological changes to dentin surfaces. Clinical Oral Investigations, 21(4), pp.1013-1019.
- Pilloni, A., Schmidlin, P., Sahrmann, P., Sculean, A. and Rojas, M. (2018). Effectiveness of adjunctive hyaluronic acid application in coronally advanced flap in Miller class I single gingival recession sites. Clinical Oral Investigations.
- Fujioka-Kobayashi, M., Schaller, B., Kobayashi, E., Hernandez, M., Zhang, Y. and Miron, R. (2016). Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors. Journal of Clinical Medicine, 5(12), p.112.
- Taman, R., Fahmy, M., Karam, S. and El Ashwah, A. (2017). Post-extraction socket preservation with autogenous bone graft and hyaluronic acid followed by delayed implant placement. Alexandria Dental Journal, 42, pp.170-176.
- Nadershah, M. et al. (2018). The Effect of Cross-Linked Hyaluronic Acid in Surgical Extraction of Impacted Mandibular Third Molars. International Journal of Dentistry and Oral Health, 4(2).